Changes Seen in Platelets and Coagulation Profile in SARS-CoV-2 Infection

Authors

  • Anamika Priyadarshinee Department of Pathology , KIST MCTH
  • Ashish Lakhey KIST MCTH
  • Sneh Acharya
  • Samikchhya Regmi
  • Sushama Bhatta

DOI:

https://doi.org/10.61122/jkistmc256

Keywords:

Coronavirus; COVID 19; D-dimer; N:L ratio; Platelets

Abstract

Introduction: COVID-19 is a multisystemic disease with profound effects on the hematolymphoid and coagulation system. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belonging to the Corona viridae. The Objective of the study was  to evaluate the platelet and coagulation profile in patients with SARS-CoV-2 infection.

Methods: A descriptive (cross-sectional) study, conducted in KIST medical college and teaching hospital (KIST MCTH), as census data, from 1st June 2021 to 30th December 2021

Results: COVID-19 association was seen more in male patients and most of the admitted patients had moderate severity. N:L ratio was higher in 55.6% (n= 29) admitted cases. In the admitted patients of COVID thrombocytopenia was noted in only 10 patients. Forty-two patients had normal platelets. Nine patients had raised Prothrombin time and 21 patients had raised D-dimer.

Conclusion: Unlike most viral infections, COVID-19 showed systemic inflammation and DIC features with lymphopenia and increased D-dimer. Thrombocytopenia is not associated with less severe cases; thus, it cannot be used as a prognostic factor.

Author Biography

Ashish Lakhey, KIST MCTH

Associate professor

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Published

2023-07-31

How to Cite

1.
Priyadarshinee A, Lakhey A, Acharya S, Regmi S, Bhatta S. Changes Seen in Platelets and Coagulation Profile in SARS-CoV-2 Infection. J. KIST Med. Col [Internet]. 2023 Jul. 31 [cited 2024 Dec. 4];5(10):14-7. Available from: https://jkistmc.org.np/jkistmc/index.php/JKISTMC/article/view/256