Changes Seen in Platelets and Coagulation Profile in SARS-CoV-2 Infection
DOI:
https://doi.org/10.61122/jkistmc256Keywords:
Coronavirus; COVID 19; D-dimer; N:L ratio; PlateletsAbstract
Introduction: COVID-19 is a multisystemic disease with profound effects on the hematolymphoid and coagulation system. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belonging to the Corona viridae. The Objective of the study was to evaluate the platelet and coagulation profile in patients with SARS-CoV-2 infection.
Methods: A descriptive (cross-sectional) study, conducted in KIST medical college and teaching hospital (KIST MCTH), as census data, from 1st June 2021 to 30th December 2021
Results: COVID-19 association was seen more in male patients and most of the admitted patients had moderate severity. N:L ratio was higher in 55.6% (n= 29) admitted cases. In the admitted patients of COVID thrombocytopenia was noted in only 10 patients. Forty-two patients had normal platelets. Nine patients had raised Prothrombin time and 21 patients had raised D-dimer.
Conclusion: Unlike most viral infections, COVID-19 showed systemic inflammation and DIC features with lymphopenia and increased D-dimer. Thrombocytopenia is not associated with less severe cases; thus, it cannot be used as a prognostic factor.
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Copyright (c) 2024 Anamika Priyadarshinee, Ashish Lakhey, Sneh Acharya, Samikchhya Regmi, Sushama Bhatta
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