The Clinicopathological Profile of Bladder Cancer Undergoing Radical Cystectomy in Nepal: A Retrospective Analysis

Abstract

Introduction: Bladder cancer is the 10th most common cancer diagnosed worldwide and the 13th most commonly diagnosed cancer in Nepal. Radical cystectomy with urinary diversion is considered the standard of care for high-risk diseases. This study aims to analyse the clinicopathological profile of bladder cancer patients that underwent radical cystectomy.

Methods: All patients who underwent Radical Cystectomy between January 2007 to December 2016 at BP Koirala Memorial Cancer hospital were evaluated. Their perioperative data were collected. Qualitative data were represented as mean and standard deviation whereas categorical variables were expressed as frequencies and percentages of an appropriate denominator.

Result: Among 142 cases that met the inclusion criteria, the median age was 60 years. Most were male (83.8%) and had a past history of smoking. Urinary diversion after cystectomy with ileal conduit was done in 83% of patients and orthotropic neobladder reconstruction was done in 17% of patients. Mean blood loss was 925.16 ± 568 ml and operation duration was 327.11± 86.13 min. Most cases had Urothelial Carcinoma (88.2%). About two-third of the cases (66.2%) had NO stage and less than half of the cases (44.4%) had the T2 stage.

Conclusion: Bladder cancer is more prevalent among elderly men who consumed tobacco. Urothelial Carcinoma is the most common histological type.