Pyogenic infections in Eastern Nepal with special reference to Staphylococcus aureus

Authors

  • Pratima Shah Department of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal
  • Rinku Sah Department of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal
  • Keshav Rai Department of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal
  • Basudha Khanal Department of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal
  • Narayan Raj Bhattarai Department of Microbiology, B. P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal

Keywords:

methicillin resistance Staphylococcus aureus, multi-drug resistance, pyogenic infection, Staphylococcus aureus

Abstract

Introduction: Pyogenic infections are significant clinical condition associated with wide variety of pyogenic bacteria, predominantly Staphylococcus aureus. A rising trend of multi-drug resistance pathogens, in particular methicillin resistant Staphylococcus aureus (MRSA) are reported with pyogenic infections globally. It is important to identify the microbial pathogen for rapid institution of optimal antimicrobial agent in early stage to overcome the life threatening complications. This study was planned to determine the clinically significant bacterial profile of pyogenic infection special reference to Staphylococcus aureus and its antimicrobial susceptibility pattern.

Methods: A Descriptive cross-sectional study was conducted at B. P. Koirala Institute of Health Sciences. Wound swabs and pus aspirates were collected from each patient suspecting pyogenic infection. Following standard microbiological methods, isolation and identification was done in the Department of Microbiology. Antimicrobial susceptibility test along with MRSA detection was performed following Clinical and Laboratory Standard Institute.

Results: Of the 1863 specimens, culture was positive in 50.8% of cases. Staphylococcus aureus (39.5%) was the leading cause of pyogenic infection followed by Escherichia coli (12.2%), Acinetobacter baumani complex (10.1%). Staphylococcus aureus was sensitive to vancomycin (100%), linezolid (100%), amikacin (79.70%), cotrimoxazole (77.60%), gentamicin (64.53%), ciprofloxacin (46.06%), cefalexin (37.6%), ceftriaxone (34.66%), erythromycin (27.46%), penicillin (6.66%), cefoxitin (37.86%). Staphylococcus aureus was multidrug resistant with methicillin resistant rate of 51.2 %.

Conclusion: Pyogenic wound infections predominantely caused by high rates of methicillin resistance Staphylococcus aureus with multiple drug resistance is highly alarming. Therefore, continuous surveillance should be done to update the resistance pattern and guide rational use of antibiotics.

 

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Published

2023-05-19

How to Cite

1.
Shah P, Sah R, Rai K, Khanal B, Bhattarai NR. Pyogenic infections in Eastern Nepal with special reference to Staphylococcus aureus. J. KIST Med. Col [Internet]. 2023 May 19 [cited 2024 Dec. 4];5(9):43-7. Available from: https://jkistmc.org.np/jkistmc/index.php/JKISTMC/article/view/262

Issue

Vol. 5 No. 9 (2023): Journal of KIST Medical College

Section

Original Article

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