Association of Serum Lipids and Vitamin B12 in Subjects with type 2 Diabetes Mellitus

Authors

  • Naval Kishor Yadav Department of Biochemistry, College of Medical Sciences

DOI:

https://doi.org/10.61122/jkistmc300

Keywords:

Serum lipids, Type 2 diabetes mellitus ,Vitamin B12

Abstract

Introduction: T2DM is a common health problem worldwide and associated with dyslipidemia. Many study reported, vitamin B12 deficiency is prevalent in T2DM patients. Therefore, the aim of this study was to study association of serum lipids with vitamin B12 in patients with T2DM. 

Methods; This study was a cross-sectional and hospital based, carried out among 155 patients with T2DM. The Sociodemographic variables were collected and biochemical parameters were estimated in blood of all the study population. The categorical data were reported in percentage and numerical data were presented as mean±SD. The descriptive analysis was performed to get mean, standard deviation and percentage. The association between serum lipids and vitamin B12 were analyzed using Pearson’s correlation. P<0.05 was considered as a significance.

Results: The mean age of study subjects were 52.21 ± 15.78 and BMI were 28.10 ± 5.21. The vitamin B12 deficiency was noticed in 28.38% patients with diabetes mellitus. The serum total cholesterol, triglycerides, LDL-C, VLDL, Non-HDL-C, TC/HDL-C ratio and TG/HDL-C ratio showed negative association with vitamin B12 levels in patients with diabetes mellitus. However, serum HDL-C showed positive association with vitamin B12 levels. The association was statistically significant (p<0.001).

Conclusion: Present study showed the adverse association between vitamin B12 and serum total cholesterol, triglycerides and LDL-cholesterol and positive association with HDL-cholesterol in type 2 diabetes patients.

 

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Published

2024-07-31

How to Cite

1.
Yadav NK. Association of Serum Lipids and Vitamin B12 in Subjects with type 2 Diabetes Mellitus. J. KIST Med. Col [Internet]. 2024 Jul. 31 [cited 2024 Nov. 21];6(12):23-8. Available from: https://jkistmc.org.np/jkistmc/index.php/JKISTMC/article/view/300